Respiratory and Autonomic Plasticity Following Intermittent Hypoxia

Completed · Early Phase 1

Conditions studied: Sleep Apnea Syndromes

In brief

The prevalence of obstructive sleep apnea is high in the Veteran population. If not treated promptly, sleep apnea may result in daytime fatigue which may lead to increased prevalence of accidents while driving or in the workplace. Recent large scale epidemiological studies have shown that the prevalence of excessive daytime sleepiness increases in individuals who suffer from obstructive sleep apnea. Obstructive sleep apnea may also result in the development of hypertension and other cardiovascular disorders. Previous findings have shown that subjects with sleep apnea have a greater risk for developing coronary vascular disease compared to individuals that do not suffer from sleep apnea Thus, a significant amount of evidence suggests that sleep apnea is a major health concern in the Veteran population. Consequently, determining the mechanisms that may impact on the severity of sleep apnea and increase the prevalence of cardiovascular incidents associated with this disorder is important, as is discovering novel treatments.

Key facts

Study ID

NCT00860743

Run by

VA Office of Research and Development

People needed

63

Starts

2009-09-01

Expected to finish

2013-09-01

Last updated by the study team

2017-11-01

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Characteristics of OSA subject population:
• Body mass index < 30 kg/m2.
• 20 to 40 years old.
• Newly diagnosed never-treated mild to moderate sleep apnea (i.e. 50 > apnea/hypopnea index >10 events per hour - average nocturnal oxygen saturation > 90%).
• Not pregnant.
• Free of any other known medical conditions.
• Not taking any medication.
• Non-smokers with normal lung function.
• Minimal alcohol consumption (i.e. no more than the equivalent of a glass of wine/day).
• Characteristics of control group population:
• Body mass index < 30 kg/m2.
• 20 to 40 years old.
• Apnea/hypopnea index < 5 events per hour.
• Not pregnant.
• Free of any known medical conditions.
• Not taking any medication.
• Non-smokers with normal lung function.
• Minimal alcohol consumption (i.e. no more than the equivalent of a glass of wine/day).

You may not qualify if…

• Anything not in inclusion criteria.

Where it is running

• John D. Dingell VA Medical Center, Detroit — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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