Radiosurgery or Open Surgery for Epilepsy Trial
Completed · Not applicable
Conditions studied: Epilepsy
In brief
This study will compare radiosurgery (focused radiation, Gamma Knife Radiosurgery) with temporal lobectomy (standard surgical care) as a treatment of temporal lobe epilepsy. Patients who have seizures that begin in their temporal lobe that are not controlled with medications into the trial will be offered entry. Patients with a high likelihood of having their seizures controlled with open surgery will have treatment randomized between the standard surgery and radiosurgery. A prior study has shown that focused radiation (radiosurgery) may also reduce or eliminate seizures arising from the temporal lobe. The main study hypothesis is that radiosurgery is as safe and effective as temporal lobectomy in treating patients with seizures arising from the medial temporal lobe.
Key facts
- Study ID
- NCT00860145
- Run by
- University of California, San Francisco
- People needed
- 61
- Starts
- 2009-09-01
- Expected to finish
- 2016-07-01
- Last updated by the study team
- 2018-05-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- University of California, San Diego — La Jolla, California, United States
- University of Southern California — Los Angeles, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Indiana University — Indianapolis, Indiana, United States
- University of Kentucky — Lexington, Kentucky, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Columbia University — New York, New York, United States
- State University of New York, Upstate Medical Center — Syracuse, New York, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- University of Virginia — Charlottesville, Virginia, United States
- University of Washington — Seattle, Washington, United States
- West Virginia University — Morgantown, West Virginia, United States
- All India Institute of Medical Sciences (AIIMS) — New Delhi, India
Full record on ClinicalTrials.gov
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