Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea, Hypoxemia

In brief

Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease. This research will investigate one potential mechanism leading to the development of cardiovascular disorder, specifically, the blockage of blood vessels called "vascular occlusion", in subjects with sleep apnea. A group of healthy controls will be used for comparison. All subjects will undergo clinical evaluation followed by an overnight sleep study and a morning blood draw. Subjects with sleep apnea will be treated according to standard clinical management and followed under the research protocol for one month. At the end of one month, a repeat blood draw will be performed on the sleep apnea subjects for comparative analysis. If a control subject is found to have any abnormality during this research study, he or she will be referred for further clinical evaluation.

Key facts

Study ID

NCT00859950

Run by

Weill Medical College of Cornell University

People needed

70

Starts

2009-04-01

Expected to finish

2015-08-01

Last updated by the study team

2019-02-04

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 21 years or older
• Presence of intermittent hypoxemia (IH) and obstructive sleep apnea (OSA)
• No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence of underlying vascular disease

You may not qualify if…

• Smoking
• Pregnancy
• Known cardiovascular disease, stroke, or diabetes
• Current or previous treatment for sleep apnea
• Central or Cheyne-Stokes sleep apnea
• Use of supplemental oxygen at night
• Alcohol abuse
• Regular use of sedatives
• Regular use of aspirin or cholesterol lowering agents
• Study Group 2: Normal Controls
• Inclusion Criteria:
• 21 years or older
• No diagnosis of intermittent hypoxemia (IH) or obstructive sleep apnea (OSA)
• No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence of underlying vascular disease
• Exclusion Criteria:
• Smoking
• Pregnancy
• Known cardiovascular disease, stroke, or diabetes
• Use of supplemental oxygen at night
• Alcohol abuse
• Regular use of sedatives
• Regular use of aspirin or cholesterol lowering agents

Where it is running

• Weill Cornell Medical College - Weill Cornell Pulmonary Associates — New York, New York, United States

Full record on ClinicalTrials.gov

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