177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer

Running, not enrolling · Phase 2

Conditions studied: Prostate Cancer

In brief

The purpose of this study is to test the effectiveness of the experimental drug, 177Lu-J591 in combination with ketoconazole and hydrocortisone against prostate cancer.

Key facts

Study ID

NCT00859781

Run by

Weill Medical College of Cornell University

People needed

55

Starts

2009-06-01

Expected to finish

2026-09-01

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed adenocarcinoma of the prostate previously treated with surgery and/or radiotherapy.
• Biochemical progression (rising PSA) after medical or surgical castration
• High risk of systemic progression defined as:
• Rising PSA as defined above and either:
• Absolute PSA > 20 ng/mL AND/OR
• PSA doubling time < 8 months
• No evidence of local recurrence or distant metastases
• Age >18 years.
• Serum testosterone < 50 ng/ml
• Patients capable of fathering children must agree to use an effective method of contraception for the duration of the trial.
• Subjects on bisphosphonate therapy must be on a stable dose and must have started therapy > 4 weeks prior to protocol therapy.
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Use of red blood cell or platelet transfusions within 4 weeks of treatment
• Use of hematopoietic growth factors within 4 weeks of treatment
• Prior cytotoxic chemotherapy and/or radiation therapy within 4 weeks of treatment
• Prior radiation therapy encompassing >25% of skeleton (see Appendix C)
• Prior treatment with 89Strontium or 153Samarium containing compounds (e.g. Metastron®, Quadramet®)
• Platelet count <150,000/mm3 or known primary qualitative platelet disorder
• Absolute neutrophil count (ANC) <2,000/mm3
• Hematocrit <30 percent and Hemoglobin < 10 g/dL
• Abnormal coagulation profile (PT or INR, PTT > 1.3x ULN) unless on therapeutic anticoagulation - see concomitant meds section
• Serum creatinine >2.5 mg/dL
• AST (SGOT) >2x ULN
• Bilirubin (total) >1.5x ULN; subjects with Gilbert's syndrome will be allowed if direct bilirubin is within institutional normal limits
• Active serious infection
• Active angina pectoris or NY Heart Association Class III-IV
• ECOG Performance Status > 2
• Life expectancy <12 months
• History of deep vein thrombosis and/or pulmonary embolus within 1 month of study entry
• Other serious illness(es) involving the cardiac, respiratory, CNS, renal, hepatic or hematological organ systems which might preclude completion of this study or interfere with determination of causality of any adverse effects experienced in this study
• Prior investigational therapy (medications or devices) within 4 weeks of treatment. Furthermore, other investigational therapy is not permitted during the treatment phase.
• Prior use of ketoconazole for the purposes of prostate cancer therapy for greater than 1 month
• Known history of HIV. The effects of J591 are unknown in this population. Furthermore, ketoconazole has many well-described drug-drug interactions which could affect antiviral therapy. If necessary, this population will be studied separately.
• Currently active other malignancy other than non-melanoma skin cancer. Patients are considered not to have "currently active" malignancy if they have completed any necessary therapy and are considered by their physician to be at less than 30% risk of relapse.
• Known history of known myelodysplastic syndrome
• Adrenal hormone inhibitors (other than ketoconazole) within 4 weeks prior to study enrollment
• Finasteride (Propecia® or Proscar®) or dutasteride (Avodart®) within 4 weeks of enrollment

Where it is running

• Cedars Sinai — Los Angeles, California, United States
• USC/Norris Comprehensive cancer center — Los Angeles, California, United States
• Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• The University of Kansas Cancer Center — Westwood, Kansas, United States
• Weill Cornell Medical College — New York, New York, United States
• UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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