Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study A
Completed · Not applicable
Conditions studied: Diabetes Mellitus, Type 1
In brief
Glutathione is normally present at high (millimolar) levels in blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by reactive oxygen species produced by the metabolism of most nutrients, including glucose. Glutathione is a small peptide made from 3 amino acids, glutamate, cysteine, and glycine. This study is looking at how blood sugar levels may affect the way glutathione is made and used by the body. Since glutathione is continuously synthesized and broken down, the amount of glutathione present in blood depends on the balance between its rate of synthesis and its rate of use. In earlier studies, the investigators found that in poorly controlled diabetic teenagers, glutathione was low, not because its production was decreased, but because it was used at an excessive rate. In this study, the investigators want to determine how short-term changes in blood sugar levels affect glutathione levels. This will help improve our understanding of how diabetes affects metabolism.
Key facts
- Study ID
- NCT00858897
- Run by
- Nemours Children's Clinic
- People needed
- 10
- Starts
- 2007-06-01
- Expected to finish
- 2009-02-01
- Last updated by the study team
- 2023-07-10
Who can join
Age: 14 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Type 1 diabetes, using usual criteria such as: glycosuria, hyperglycemia prior to treatment
- BMI <25 kg/m2
- Age 14-18
- HbA1c>7.5%
- No evidence of diabetic complications
- Written informed consent from parents or legal guardian, and assent from patient
You may not qualify if…
- Presence of significant anemia (hemoglobin <11g/dL)
- Presence of intercurrent illness such as infection
- Presence of chronic disease such as other endocrine deficiency, chronic respiratory or cardiac disease
- Chronic use of medication other than insulin
- Use of vitamin or mineral supplements within 2 weeks of study
Where it is running
- Nemours Children's Clinic — Jacksonville, Florida, United States
Full record on ClinicalTrials.gov
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