Genetic Predisposition-Chronic Nephrotoxicity From CI-Liver Transplant Recipients-Potential Correlation-Urinary Biomarkers
Completed
Conditions studied: Complication of Transplanted Liver
In brief
The purpose of this study is to determine the relationship between genomic variants of components of the renin-angiotensin system and the development of kidney problems due to Calcineurin-inhibitors post liver transplant.Also the investigator will evaluate the relationship between chronic renal failure post liver transplant and the risk of death. A sample of blood and urine wil be examined to see how the patient's genes are arranged in order to determine the difference in genes between people which may explain who will develop chronic renal failure after having received a liver transplant. The results may help us classify patients according to their risk and allow us to target their treatment to their individual need. In addition, it may ultimately lead to treatments that slows or prevents the development of chronic rejection.
Key facts
- Study ID
- NCT00857844
- Run by
- Northwestern University
- People needed
- 207
- Starts
- 2007-07-01
- Expected to finish
- 2012-05-01
- Last updated by the study team
- 2013-05-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed consent
- Males and females > 18 years old
- Liver transplant recipients who have received a liver transplant at least 6 months ago
- Liver transplant recipients receiving a maintenance immunosuppression.
You may not qualify if…
- Legal incapacity and/or other circumstances rendering the patient unable to understand the nature, scope and possible consequences of the study
- Pre-existing known kidney disease before liver transplantation
- Multi-organ transplant
Where it is running
- Northwestern Memorial Hospital — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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