Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

Completed · Not applicable

Conditions studied: HIV (Human Immunodeficiency Virus), Metabolic Syndrome, HIV Infections

In brief

Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.

Key facts

Study ID

NCT00857298

Run by

Washington University School of Medicine

People needed

20

Starts

2009-02-01

Expected to finish

2014-07-01

Last updated by the study team

2015-02-16

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Sedentary
• Obese
• Have either dyslipidemia (HDL < 50 or triglycerides > 150), waist circumference > 88cm, and impaired glucose tolerance or homeostasis model assessment value of > 3
• Subjects with HIV-MS must have been receiving HAART for > 6 months

You may not qualify if…

• Medication changes in the last 3 months
• Diabetes mellitus
• Medical problems that in the opinion of the principal investigator may interfere with patient safety
• Substance abuse

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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