Time Based Strategy to Reduce Clopidogrel Associated Bleeding Related to Coronary Artery Bypass Graft (CABG)

Status unconfirmed · Not applicable

Conditions studied: Coronary Artery Disease

In brief

Purpose: In patients with coronary artery disease, aspirin and Plavix are used increasingly to prevent the formation of blood clots in the coronary arteries. These drugs exert their beneficial effects by irreversibly blocking platelets, the compounds found in blood responsible for clotting after an injury or during a heart attack. However, these effects also place patients at increased risk for bleeding after coronary artery bypass surgery. Therefore, it is currently recommended to withhold Plavix therapy for 5 days before undergoing surgery in order to reduce the incidence of bleeding. However, it has been repeatedly shown that Plavix exerts variable effects on different patients, which may be partially explained by poor absorption, drug-drug interaction, and by variations in deoxyribonucleic acid (DNA) which constitutes your genes. In addition, the time required for platelets to regain function after Plavix treatment has been shown to vary between patients. Therefore, by measuring platelet function, it may be possible to determine the optimal amount of time required to withhold Plavix before undergoing bypass surgery, which may improve rates of bleeding following the procedure. The purpose of this study is to classify patients into groups based on platelet function in order to define the ideal time period for delaying surgery. By analyzing the amount of time required for platelet recovery, it is expected that surgery-related bleeding will decrease without increasing the risk of blood clot formation. Eligibility: Approximately 200 patients requiring CABG will be enrolled at Sinai Hospital, which is the only site where this study is being conducted. To be eligible you must: * Be able to provide written informed consent. * Be between the ages of 18-85 and require CABG. * Currently be on aspirin therapy (81-325mg).

Key facts

Study ID: NCT00857155
Run by: LifeBridge Health
People needed: 200
Starts: 2009-01-01
Expected to finish: 2011-02-01
Last updated by the study team: 2009-03-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients must provide written informed consent.
Patients must currently be on aspirin therapy (81-325 mg).
Male or female patients between the ages of 18-85 requiring CABG.

You may not qualify if…

Patients undergoing emergent surgery following failed percutaneous coronary revascularization.
Patients with a history of previous cardiac surgery and patients needing concomitant valvular surgery.
Pre-operative exposure to either coumadin or platelet GPIIb/IIIa inhibitors.
Patients with a history of bleeding diathesis.
Patients with an activated partial thrombin time >1.5 normal.
Patients with platelet count <120,000/mm3.
Patients with hematocrit <30%.
Patients with creatinine clearance <30mL/min.
Patients with known active hepatic disease.
Patients with any other condition that, in the opinion of the investigator, may either put the patient at risk or influence the result of the study (e.g. malignancy, limiting life expectancy, noncompliance).

Where it is running

Sinai Hospital — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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