The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects
Completed · Phase 3 · Has a placebo group
Conditions studied: Weight Loss, Obesity
In brief
Exenatide is an incretin-like drug that has been approved for treatment of type 2 diabetes; it improves glycemia by increasing insulin and decreasing glucagon secretion by pancreatic islet cells and delaying gastric emptying. This randomized, placebo-controlled study is to evaluate whether exenatide over a 5 week period in non-diabetic obese subjects may lead to weight loss. To control for variability in individual response to weight loss treatment, this study will assess the role of exenatide in changing food intake and energy expenditure as possible sources of weight loss. This study will also evaluate the safety profile of exenatide in non-diabetic obese people. Additional assessments will evaluate changes in body fat and hormones involved in the sensations of hunger and fullness.
Key facts
- Study ID
- NCT00856609
- Run by
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- People needed
- 150
- Starts
- 2009-03-03
- Expected to finish
- 2016-09-19
- Last updated by the study team
- 2019-06-04
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Age < 18 years
- Use of other medications to treat obesity including medications obtained over the counter or internet, orlistat (Xenical, Alli), sibutramine (Meridia), topiramate (with or without phentermine (Qsymia), phentermine (Adipex P) or lorcaserin (Belviq) within the past 6 months
- History of an eating disorder including anorexia or bulimia
- History of surgery for the treatment of obesity (gastric banding, gastric bypass)
- Diagnosis of type 1 or type 2 diabetes mellitus according to American Diabetes Association guidelines
- Previous exposure to exenatide
- Uncontrolled hypertension as defined by a blood pressure of 150/90 on two or more occasions or use of antihypertensive medications which may affect energy expenditure including alpha blockers, beta blockers, angiotensin receptor blockers or inhibitors of angiotensin converting enzyme
- Current use of tobacco products, marijuana, amphetamines, cocaine or intravenous drug use
- Chronic ethanol use (> 3 drinks /day)
- Endocrine disorders including hypo or hyperthyroidism (including subclinical disease), Cushing s disease, growth hormone deficiency or other pituitary diseases
- History of pancreatitis
- Personal or family history of multiple endocrine neoplasia (MEN)-2 or medullary thyroid cancer
- History of unresolved gallstones
- Hyperamylasemia
- Fasting triglyceride level greater than or equal to 500
- Gastroparesis
- Inflammatory bowel disease or malabsorption disorders
- Malignancy treated with chemotherapy or radiation within the past 5 years
- Current clinical depression, diagnosis of psychosis or recent use of psychotropic medication
- Pregnancy within past 6 months
- Breastfeeding
- Failure to use medically approved contraceptive methods if subject is female
- Liver function abnormalities (transaminases greater than twice normal)
- Renal insufficiency (creatinine clearance < 50 ml/min)
- History of chronic infection including tuberculosis, coccidiomycoses, lyme disease or HIV infection
Where it is running
- NIDDK, Phoenix — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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