S0800, Nab-Paclitaxel, Doxorubicin, Cyclophosphamide, and Pegfilgrastim With or Without Bevacizumab in Treating Women With Inflammatory or Locally Advanced Breast Cancer
Completed · Phase 2
Conditions studied: Breast Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them. Others interfere with the ability of tumor cells to grow and spread. Bevacizumab may also may stop the growth of tumor cells by blocking blood flow to the tumor. Giving these treatments before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known which treatment regimen is more effective in treating women with breast cancer. PURPOSE: This randomized phase II trial is studying paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, cyclophosphamide, and pegfilgrastim to compare how well they work when given with or without bevacizumab in treating women with inflammatory or locally advanced breast cancer.
Key facts
- Study ID
- NCT00856492
- Run by
- SWOG Cancer Research Network
- People needed
- 215
- Starts
- 2010-04-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2017-06-27
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States
- Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center — Burbank, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- East Bay Radiation Oncology Center — Castro Valley, California, United States
- Valley Medical Oncology Consultants - Castro Valley — Castro Valley, California, United States
- Valley Medical Oncology — Fremont, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center — Long Beach, California, United States
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Contra Costa Regional Medical Center — Martinez, California, United States
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
- El Camino Hospital Cancer Center — Mountain View, California, United States
- Sutter Health - Western Division Cancer Research Group — Novato, California, United States
- Highland General Hospital — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Larry G Strieff MD Medical Corporation — Oakland, California, United States
- Tom K Lee, Incorporated — Oakland, California, United States
- Epic Care - Oakland — Oakland, California, United States
- St. Joseph Hospital Regional Cancer Center - Orange — Orange, California, United States
- Desert Regional Medical Center Comprehensive Cancer Center — Palm Springs, California, United States
- Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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