NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naïve, KRAS Mutant, Colorectal Cancer

Completed · Phase 2

Conditions studied: Colorectal Cancer

In brief

This study will evaluate whether NKTR-102, an investigational drug has an anti-tumor effect in patients with colorectal cancer. This study will also evaluate how the safety and anti-tumor activity of NKTR-102 compares with irinotecan, a cancer drug that is approved for use in the US for treatment of patients with certain types of colorectal cancer.

Key facts

Study ID

NCT00856375

Run by

Nektar Therapeutics

People needed

83

Starts

2008-12-01

Expected to finish

2014-12-01

Last updated by the study team

2021-07-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• metastatic colorectal cancer
• tumor with k-ras mutation

You may not qualify if…

• More than 1 prior regimen for treatment of metastatic disease

Where it is running

• Investigator Site - Peoria — Peoria, Arizona, United States
• Investigator Site - Burbank — Burbank, California, United States
• Investigator Site - Los Angeles — Los Angeles, California, United States
• Investigator Site - Vallejo — Vallejo, California, United States
• Investigator Site - Centralia — Centralia, Illinois, United States
• Investigator Site - Louisville — Louisville, Kentucky, United States
• Investigator Site - Detroit — Detroit, Michigan, United States
• Investigator Site - Buffalo — Buffalo, New York, United States
• Investigator Site - Knoxville — Knoxville, Tennessee, United States
• Investigator Site - Antwerp — Antwerp, Belgium
• Investigator Site - Celle — Celle, Germany
• Investigator Site - Karlsruhe — Karlsruhe, Germany
• Investigator Site - Hyderabad — Hyderabad, Andhra Pradesh, India
• Investigator Site - Ahmedabad — Ahmedabad, Gujarat, India
• Investigator Site - Bangalore — Bangalore, Karnatak, India
• Investigator Site - Bangalore — Bangalore, Karnatak, India
• Investigator Site - Kochi — Kochi, Kerata, India
• Investigator Site - Mumbai — Mumbai, Maharashtra, India
• Investigator Site - Kolkata — Kolkata, West Benagal, India
• Investigator Site - Kolkata — Kolkata, West Bengal, India
• Investigator Site - Elche — Elche, Spain
• Investigator Site - Madrid — Madrid, Spain
• Investigator Site - Aberdeen — Aberdeen, Scotland, United Kingdom
• Investigator Site - Manchester — Manchester, United Kingdom

Full record on ClinicalTrials.gov

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