Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea

Completed · Phase 4

Conditions studied: Papulopustular Rosacea

In brief

Subjects with moderate papulopustular rosacea will be treated either with azelaic acid 15% gel topically plus an anti-inflammatory dose of doxycyline (40mg) daily or with metronidazole 1% gel topically once daily plus an anti-inflammatory dose of doxycycline (40mg) over at total of twelve weeks to determine the rapidity of improvement, and the length of time to reach 25%, 50% and 75% clearing compared to baseline.

Key facts

Study ID

NCT00855595

Run by

LEO Pharma

People needed

207

Starts

2009-02-01

Expected to finish

2009-07-01

Last updated by the study team

2020-03-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Moderate papulopustular rosacea (IGA>4) with a minimum of 10 and no more than 50 inflammatory lesions and persistent erythema with or without telangiectasia

You may not qualify if…

• Sensitivity to any of the treatments used
• Co-existing conditions that would unfavorably influence the course of the disease
• Pregnant or lactating women
• Severe rosacea

Where it is running

• Study site — Birmingham, Alabama, United States
• Study site — Denver, Colorado, United States
• Study site — West Palm Beach, Florida, United States
• Study site — Boston, Massachusetts, United States
• Study site — Warren, Michigan, United States
• Study site — Fridley, Minnesota, United States
• Study site — Henderson, Nevada, United States
• Study site — Albuquerque, New Mexico, United States
• Study site — Stony Brook, New York, United States
• Study site — Mason, Ohio, United States
• Study site — Portland, Oregon, United States
• Study site — Austin, Texas, United States
• Study site — Dallas, Texas, United States
• Study site — Houston, Texas, United States
• Study site — San Antonio, Texas, United States
• Study site — Salt Lake City, Utah, United States
• Study site — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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