Evaluation of Exenatide in Patients With Diabetic Neuropathy
Completed · Not applicable
Conditions studied: Type 2 Diabetes Mellitus, Diabetic Peripheral Neuropathy
In brief
This study will look at whether or not the medication exenatide improves signs and symptoms of diabetic peripheral neuropathy in people with type 2 diabetes and mild to moderate diabetic peripheral neuropathy.
Key facts
- Study ID
- NCT00855439
- Run by
- University of Michigan
- People needed
- 46
- Starts
- 2008-06-01
- Expected to finish
- 2014-05-01
- Last updated by the study team
- 2017-03-01
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Type 2 diabetes treated with one or more oral agents
- Persistent fasting glucose > 140 mg/dl or HbA1c > 7%
- Stable and maximally effective doses of one or more oral agents for 3 months
- Presence of diabetic peripheral neuropathy
- Age between 18 and 70 years
- No risk factors or other causes of neuropathy
- Willingness and capacity to sign the Institutional Review Board approved consent form and cooperate with the medical procedures for study duration
You may not qualify if…
- Nursing mothers or pregnant women
- A history of previous kidney, pancreas or cardiac transplantation
- A past history of neuropathy (independent of diabetes) or with a disease known to be associated with neuropathy (e.g., hepatitis C, end stage renal disease, lupus)
- Amputation of any part of either lower extremity for any reason or traumatic loss of any part of either lower extremity or congenital absence or severe deformity of lower extremity
- HbA1c > 10%
- Participation in an experimental medication trial within 3 months of starting the study.
- Undergoing therapy for malignant disease other than basal- or squamous cell carcinoma
- Requiring long-term glucocorticoid therapy
- Inability or unwillingness to comply with the protocol
Where it is running
- The University of Michigan Health System — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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