A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults

Withdrawn before enrolling · Not applicable

Conditions studied: Pharmacokinetics

In brief

This study is being done to determine the systemic absorption of nasally inhaled acetaminophen (Tylenol®) versus orally ingested acetaminophen by comparing the serum drug concentrations of the two groups obtained at various times after study drug administration.

Key facts

Study ID

NCT00855049

Run by

University of Texas Southwestern Medical Center

People needed

0

Starts

2009-04-01

Expected to finish

2009-12-01

Last updated by the study team

2019-01-22

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers 18 to 45 years of age

You may not qualify if…

• Known hypersensitivity to acetaminophen
• Prior dosing of acetaminophen or product containing acetaminophen in the preceding 7 days
• Hepatic insufficiency and/or failure, or any known liver disease
• History of nasal polyps
• History of nasal trauma in past 14 days
• History of nasal bleeding in past 14 days
• History of asthma, emphysema or any serious respiratory diseases
• Pregnancy or breastfeeding

Where it is running

• UT Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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