Stereotactic Radiosurgery in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer

Stopped early · Not applicable

Conditions studied: Lung Cancer

In brief

RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of stereotactic radiosurgery in treating patients with stage I or stage II non-small cell lung cancer.

Key facts

Study ID

NCT00852644

Run by

Boston Medical Center

People needed

9

Starts

2009-01-01

Expected to finish

2016-08-01

Last updated by the study team

2018-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DISEASE CHARACTERISTICS:
• Histologically confirmed non-small cell lung cancer
• Stage I or II disease (T1-3, N0, M0)
• T2 or T3 tumor ≤ 5 cm
• No T3 tumors involving the central chest or mediastinum (only chest wall involvement allowed)
• Tumor deemed technically resectable, in the opinion of an experienced thoracic surgeon, AND patient deemed "medically inoperable"
• Patients with fluorodeoxyglucose (FDG)-avidity in mediastinal lymph nodes are eligible provided they are able to undergo mediastinoscopy to confirm N0 status
• PATIENT CHARACTERISTICS:
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Not pregnant or nursing
• Fertile patients must use effective contraception during and for ≥ 6 months after completion of study treatment

You may not qualify if…

• No history of contrast allergy
• No psychological issues that would preclude the completion of study treatment
• PRIOR CONCURRENT THERAPY:
• No prior radiotherapy or chemotherapy
• No suspected nodal metastasis that cannot be falsified by mediastinoscopy (i.e., hilar or mediastinal nodes that are either fludeoxyglucose F 18 [FDG]-avid or measure > 1 cm in short axis diameter on CT scan)
• No tumor within or touching the proximal bronchial tree, defined as a volume of 2 cm in all directions around the proximal bronchial tree (carina, right and left main stem bronchi, right and left upper lobe bronchi, bronchus intermedius, right middle lobe bronchus, lingular bronchus, right and left lower lobe bronchi)

Where it is running

• Boston University Cancer Research Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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