Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial

Completed · Phase 3

Conditions studied: Bipolar Disorder, Major Depressive Episode

In brief

The purpose of this study is to understand the efficacy of light therapy for bipolar depression.

Key facts

Study ID

NCT00852592

Run by

Northwestern University

People needed

46

Starts

2009-05-01

Expected to finish

2015-02-01

Last updated by the study team

2016-11-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18-65 years
• DSM-IV Criteria BD I or II depressive episode,
• SIGH-ADS >20; duration >2 weeks.
• Stable dose antidepressant drug >8 weeks with concurrent antimanic drug
• Controlled thyroid disease
• Subjects with preexisting eye diseases will be included.
• Able to provide informed consent
• Stable minimum dose antimanic drug >4weeks: lithium 0.5 mEq/L, divalproex Na 50 mcg/mL, olanzapine 5mg daily, carbamazepine 4mg/L; lamotrigine 100mg daily, risperidone 2mg daily, quetiapine 400 mg daily, ziprasidone 10 mg bid, and aripiprazole 5 mg qd.
• Stable unchanged psychotherapy for >16weeks

You may not qualify if…

• The following eye diseases: retinal disease, cataract surgery and lens removal, macular degeneration,
• Taking photosensitizing drugs such as phenothiazines (chlorpromazine), antimalarial drugs, melatonin and hypericum.
• Acute psychosis (DSM-IV Criteria)
• Rapid cycling in the past 1 year
• Obsessive compulsive disorder
• Alcohol or substance abuse or dependence in the past 6 months.
• MRS>5
• Recent history of a suicide attempt (3 months) or active suicidal Ideation (SIGHADS item H11 >2)
• Beta-adrenergic blockers, exogenous melatonin, chronic NSAIDS

Where it is running

• University of Pittsburgh, Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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