Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy

NO_LONGER_AVAILABLE

Conditions studied: Leprosy

In brief

Clofazimine has shown effectiveness in the treatment of leprosy for many years. The World Health Organization and the National Hansen's Disease Program consider clofazamine to be standard therapy for treatment of multibacillary leprosy. In recent years, the availability of the drug has become limited and is currently available only under a research protocol and is considered "investigational." Use of Clofazamine in patients presenting with lepromatous leprosy is necessary for patients exhibiting nerve involvement or lesions resistant to other therapies. This drug will be used prospectively for patients who require treatment of leprosy as deemed appropriate by a Kaiser Permanente Southern California physician.

Key facts

Study ID

NCT00852345

Run by

Kaiser Permanente

Last updated by the study team

2015-04-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Known or suspected leprosy confirmed by skin biopsy and/or slit skin smears.
• Multibacillary leprosy (lepromatous leprosy or borderline-lepromatous).
• Paucibacillary leprosy (borderline, borderline tuberculoid, or indeterminate) if there is involvement of the cranial nerves or active acute neuritis.
• Known or suspected ENL(erythema nodosum leprosum) (a specific immune reaction with painful skin nodules and fever)
• Known or suspected dapsone-resistant leprosy or relapsed leprosy.
• Intolerance of other antileprosy antibiotic (where clofazamine is substituted as apart of multidrug regimen)

You may not qualify if…

• Uncomplicated paucibacillary leprosy which would otherwise be treated with dapsone and rifampin only.
• Known prior intolerance of Clofazamine
• Any minor (even with parental consent)
• Any fertile woman who is pregnant a specific immune reaction with painful skin rash and fever)

Where it is running

• Kaiser Permanente — Irvine, California, United States

Full record on ClinicalTrials.gov

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