Selective AV Nodal Vagal Stimulation For Reduction of the Ventricular Rate During Atrial Fibrillation

Withdrawn before enrolling

Conditions studied: Atrial Fibrillation

In brief

The study will enroll patients that are already in AF and in which open-heart surgical intervention has been scheduled. In these patients AVN-VNS will be delivered briefly (minutes) after the incision as a proof-of-concept therapy, with concomitant monitoring of the effects on the ventricular rate.

Key facts

Study ID

NCT00850980

Run by

The Cleveland Clinic

People needed

0

Starts

2009-02-01

Expected to finish

2009-12-01

Last updated by the study team

2017-02-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing open heart surgery
• Able to give Informed Consent and
• Permanent/Persistent or currently in Atrial Fibrillation

You may not qualify if…

• Minimally invasive incisions
• Previous open heart surgery
• Bleeding diathesis
• Creatinine levels greater than 2.0 mg/dl
• Active Infections, i.e. endocarditis
• Implanted ICD
• Pregnancy and nursing
• Incompetence and/or other conditions, which do not allow the patient to understand the nature, significance and scope of the study
• Patients on drugs that have cholinesterase inhibitor activity (e.g., physostigmine-like substances).

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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