Ankle Sprains and Corticospinal Excitability

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Ankle Sprain

In brief

The purpose of this study is to determine changes in the brain associated with improvement in ankle range of motion following ankle manual therapy procedures in individuals with post-acute ankle sprains

Key facts

Study ID

NCT00847769

Run by

University of Southern California

People needed

27

Starts

2008-12-01

Expected to finish

2011-08-01

Last updated by the study team

2017-04-04

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-60 years
• Onset of ankle sprain at least 2 weeks prior to enrollment
• Foot and Ankle Ability Measure Activity of Daily Living subscale score less than or equal to 80%
• Ankle dorsiflexion range of motion less than or equal to 5 degrees

You may not qualify if…

• Current status of assisted ambulation (eg, use of cane or crutches)
• Inability to bear weight through the affected extremity immediately after injury combined with tenderness to palpation of the medial and lateral malleolar zones, styloid process of the 5th metatarsal, and navicular
• Positive anterior drawer or talar tilt dimple test
• Volume of the affected limb greater than 10% of the unaffected limb
• Previous history of ligament or bony reconstructive surgery to the ankle and foot
• Concomitant injury to other lower extremity joints
• Medical conditions that serve as contraindications to mobilization/manipulation and transcranial magnetic stimulation, such as presence of pacemaker, metal in head, pregnancy, neurological disorders, recent use of stimulants or medications known to lower seizure threshold, and personal or family history of seizures

Where it is running

• University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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