Markers of Oxidative Stress Diastolic Dysfunction

Status unconfirmed

Conditions studied: Diastolic Heart Failure, Diastolic Dysfunction

In brief

This study is to look at the differences between people who have evidence of abnormal heart relaxation (diastolic dysfunction) on sound wave pictures of the heart (an echocardiogram) compared to those who do not. If you have abnormal relaxation, it can be a cause of shortness of breath or can be present without knowing about it. A condition known as oxidative stress mayb e associated with this abnormal relaxation. This condition occurs when abnormal oxygen injures heart cells. We would like to learn if patients with abnormal relaxation have increased oxidative stress.

Key facts

Study ID

NCT00846404

Run by

Emory University

People needed

50

Starts

2006-07-01

Expected to finish

2010-07-01

Last updated by the study team

2009-02-18

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age ≥ 18 years.
• Able to provide informed consent.
• Cases must have diastolic dysfunction documented by echocardiography an interval of six month before the time of enrollment.

You may not qualify if…

• Control subjects must not have diastolic dysfunction documented by echocardiography in an interval of six month before the time of enrollment.
• All subjects will be in sinus rhythm.
• All patients will have a left ventricular ejection fraction of > 55% but less than < 70%.
• All patients will have normal systolic and diastolic cardiac dimensions on the qualifying echocardiogram.

Where it is running

• Atlanta VAMC — Decatur, Georgia, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.