Asthma Exacerbation and Helium-3 MRI
Withdrawn before enrolling · Not applicable
Conditions studied: Asthma Exacerbation
In brief
The goal of this research is to use Helium-3 MRI to see the changes in airflow of the lungs at different times of an attack. These three stages are immediately after the attack, 1 month later and 4-6 months later.
Key facts
- Study ID
- NCT00846014
- Run by
- University of Massachusetts, Worcester
- People needed
- 0
- Starts
- 2009-01-01
- Expected to finish
- 2011-08-01
- Last updated by the study team
- 2012-09-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least 18 years old
- Able to speak and read English
- Acute asthma exacerbation, defined as requirement for hospitalization or emergent outpatient visit, and treatment with high dose corticosteroids ( 40mg prednisone or equivalent)
- FEV1 < 80% predicted on the day of MRI
- Attending physician agrees that patient is safe to participate on the day of the MRI scan
You may not qualify if…
- Evidence of pneumonia, based on chest radiograph obtained within 24 hours of enrollment (if performed)
- Documented fever or requirement for antibiotics
- Unable to hold breath for 10 seconds
- Active smoker or history of at least 10 pack years cigarette smoking
- Chest radiograph with active pulmonary disease, except for changes expected with asthma (hyperinflation, subsegmental atelectasis)
- Admission to ICU
- For inpatients: contraindication to leaving hospital room for MRI as determined by Attending physician and RN on day of MRI
- Any other concurrent active pulmonary disease or other unstable or active medical condition (including suspected active coronary ischemia, acute bleeding), as determined by Attending physician
- Pregnancy as self reported
- Need for cardiac monitoring
- Need supplemental oxygen at an amount of 4L/min or a facemask
Where it is running
- UMASS Medical School Advanced MRI Center — Worcester, Massachusetts, United States
Full record on ClinicalTrials.gov
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