Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients

Withdrawn before enrolling

Conditions studied: Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities, Respiratory Disorders

In brief

This research proposal has two main objectives. The first is to increase understanding of the underlying physiological interactions that occur between the cardiovascular, pulmonary, and ANS during transition between positive pressure mechanical ventilation (MV) and spontaneous breathing. The second is to determine if heart rate variability, (HRV) a reflection of autonomic nervous system (ANS) activity, and autonomic information flow (AIF), a set of nonlinear measures derived from HRV, both measured in the intensive care unit (ICU) can predict patient outcomes including successful weaning and in-hospital recovery time after an episode of cardiopulmonary compromise requiring MV. Hypothesis 1. Transitions between mechanically supported ventilation and spontaneous breathing will disturb cardiovascular synchrony, altering the relationship of HRV, AIF, respiratory rate, and blood pressure; Hypothesis 2. More normal HRV and AIF values, measured during baseline MV and sedation awakening (a period immediately prior to SBT when sedative medications are discontinued) will be associated with easier weaning, and shorter intensive care unit (ICU) and hospital lengths of stay; more abnormal measurements will be associated with longer lengths of stay; Hypothesis 3. AIF is a more sensitive predictor of successful weaning from MV than HRV.

Key facts

Study ID

NCT00844935

Run by

University of California, San Francisco

People needed

0

Starts

2011-09-01

Expected to finish

2012-12-01

Last updated by the study team

2012-03-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Receiving mechanical ventilation in medical-surgical intensive care unit;
• Eighteen years of age or older;
• Expectation of receiving initial spontaneous breathing trial within the next 24 hours.

You may not qualify if…

• Pregnant;
• Expectation of non-survival when ventilator is discontinued;
• Cardiac rhythm of atrial fibrillation;
• Paced cardiac rhythm.

Where it is running

• University of California, San Francisco Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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