Broccoli Sprout Extract in Treating Women Who Have Had a Mammogram and Breast Biopsy
Completed · Phase 2 · Has a placebo group
Conditions studied: Breast Cancer, Precancerous Condition
In brief
RATIONALE: Broccoli sprout extract supplements may slow the growth of tumor cells or abnormal cells and may be an effective treatment for ductal carcinoma in situ and/or atypical ductal hyperplasia. PURPOSE: This randomized phase II trial is studying how well broccoli sprout extract works in treating women with a diagnosis of breast cancer, ductal carcinoma in situ and/or atypical ductal hyperplasia.
Key facts
- Study ID
- NCT00843167
- Run by
- OHSU Knight Cancer Institute
- People needed
- 54
- Starts
- 2009-08-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2017-04-27
Who can join
Age: 21 and older, up to 120. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Diagnostic mammogram
- English speaking
You may not qualify if…
- Pregnancy (as determined by urine human chorionic gonadotropin (hCG) test)
- No biopsy referral after diagnostic mammogram
- Patient reported breast feeding
- Significant active medical illness which in the opinion of the investigator would preclude protocol treatment
- History of or active liver disease or baseline total bilirubin greater than institutional upper limit of normal
- Patient reported allergy or sensitivity to cruciferous vegetables
- Use of oral antibiotics within three months prior to randomization
- Oral steroid therapy at enrollment
- Current therapy with valproate acid or SAHA
- Current use of nutrient supplements or herbal remedies containing sulforaphane and unwillingness or inability to quit 72 hours prior to randomization and for the duration of the trial
- Radiation for currently-diagnosed disease prior to or during study supplementation
- Chemotherapy for currently-diagnosed disease prior to or during study supplementation
Where it is running
- Knight Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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