Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients

Completed · Phase 4

Conditions studied: Mycoses, Fungemia, Central Nervous System Fungal Infections, Lung Diseases, Fungal

In brief

The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients

Key facts

Study ID

NCT00841971

Run by

University of Pittsburgh

People needed

200

Starts

2010-02-01

Expected to finish

2014-05-01

Last updated by the study team

2014-12-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Liver transplant recipient at increased risk for infection increased risk include any of the following:
• retransplantation
• renal replacement therapy (dialysis),
• post transplant abdominal surgery (within 21days)
• receipt of corticosteroids for greater than 14 days within the 4 weeks -preceding transplant
• ICU care for greater than 48 hours at the time of transplantation
• colonization with Candida sps within 4 weeks of transplantation
• requirement of 15 units or greater of packed red cell transfusions
• Intraoperative time exceeding 6 hours

You may not qualify if…

• Hypersensitivity to azole or echinocandin antifungal agents
• receipt of systemic antifungal therapy within 4 weeks prior to transplantation

Where it is running

• UCLA Medical Cente — Los Angeles, California, United States
• University of Miami — Miami, Florida, United States
• University of Michigan — Ann Arbor, Michigan, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Washington Medical Center — Seattle, Washington, United States
• University of Wisconsin - Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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