Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis

Completed · Phase 2 · Has a placebo group

Conditions studied: Multiple Sclerosis, Cognitive Ability, General

In brief

The purpose of this study is to see if treatment with Ginkgo improves cognitive function in people with multiple sclerosis who have cognitive problems.

Key facts

Study ID

NCT00841321

Run by

US Department of Veterans Affairs

People needed

120

Starts

2009-01-01

Expected to finish

2010-12-01

Last updated by the study team

2014-06-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of multiple sclerosis by McDonald's criteria
• Age 18 to 65 years, inclusive
• A score minus one standard deviation below the mean on one or more of the following tests: PASAT, COWAT, CVLT-II, Stroop
• EDSS 0 - 7.5, inclusive
• No Ginkgo biloba in preceding 30 days
• Native English speaker

You may not qualify if…

• Current substance abuse disorder, psychosis, or significant depression (score on the Beck Depression Inventory II (BDI -II) greater than 28
• Any significant uncontrolled medical problem including diabetes requiring insulin
• Relapse of multiple sclerosis within the 30 days before screening
• Abnormalities of coagulation or current use of anticoagulants or antiplatelet agents
• Elective surgery planned for the study period or the following four weeks
• Epilepsy or history of seizures
• Use of nifedipine, nicardipine, Saint John's Wort, papaverine, mono amine oxidase inhibitors
• Pregnancy or women not using a reliable form of contraception
• Corrected binocular visual acuity worse than 20/50 or more than one error on binocular color vision testing with the Ishihara Color Plates or sustained nystagmus or diplopia on primary gaze
• Inability to complete the neuropsychological test battery at the screening visit
• History of alcohol abuse or illicit drug use in the prior six months

Where it is running

• Portland VA Medical Center, Portland, OR — Portland, Oregon, United States
• VA Puget Sound Health Care System, Seattle — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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