Effect of Gastric Bypass-induced Weight Loss on Myocardial Structure, Function and Metabolism
Completed
Conditions studied: Obesity, Gastric Bypass
In brief
Obesity affects more than 43 million Americans and is associated with an increased incidence of heart failure, sudden death, and cardiovascular death. We have shown that increasing obesity is independently associated with potentially detrimental LV structural and functional, and metabolic changes. Thus in order to increase our understanding of the effect of obesity on the heart, we wish to study the effect of significant weight loss on these parameters.
Key facts
- Study ID
- NCT00841009
- Run by
- Washington University School of Medicine
- People needed
- 18
- Starts
- 2005-07-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2016-05-04
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects that will undergo gastric bypass surgery will be included in the study.
You may not qualify if…
- Subjects who have a history of insulin-requiring diabetes, ≥Class II hypertension, cardiac disease, major systemic disease, of smoking cigarettes with in the last 12 months, who are pregnant or taking vasoactive or lipid-lowering medications will be excluded because these conditions may affect our cardiac endpoints. Subjects unable to give informed consent will be excluded. Subjects > 350# (the weight limit of the PET table) will be excluded.
Where it is running
- Washington University in St. Louis — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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