Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases

Stopped early · Not applicable

Conditions studied: Anemia, Sickle Cell

In brief

The investigators plan to obtain skin and blood samples from healthy volunteers and patients with a benign, inherited hematologic disease to use for research to use homologous recombination to correct β-globin gene mutations in therapeutically useful cells, like autologous induced pluripotent stem cells from sickle cell anemia patients.

Key facts

Study ID

NCT00840567

Run by

Washington University School of Medicine

People needed

7

Starts

2009-02-01

Expected to finish

2010-10-01

Last updated by the study team

2013-07-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18.
• No active systemic skin infection at biopsy site.
• No allergy to lidocaine or other local anesthetics

You may not qualify if…

• ALL PATIENTS
• History of a bleeding disorder, easy bleeding, or bruising.
• Inability or unwillingness to provide informed consent.
• SICKLE CELL PATIENTS
• Platelets ≤ 50,000
• INR ≥ 1.5
• Currently bing given intravenous heparin

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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