Changes in Ectopic Fat Following Surgically Induced Weight Loss

Completed

Conditions studied: Obesity, Type 2 Diabetes

In brief

This study evaluates how ectopic fat (in the pancreas, heart, liver and skeletal muscle), visceral fat, and subcutaneous fat changes following surgically induced weight loss using gastric banding. The investigators also evaluate whether changes in pancreatic fat content correlate with improvement in beta-cell function.

Key facts

Study ID

NCT00840307

Run by

University of Texas Southwestern Medical Center

People needed

20

Starts

2008-08-01

Expected to finish

2012-12-01

Last updated by the study team

2017-12-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Greater than 18 years old
• Fully understanding and willing to undergo study procedures
• Available for follow-up
• Understand and willing to sign informed consent
• Pharmacologic agents with the potential to change ectopic fat content (i.e. pioglitazone) are allowed if the patient has been on a stable dose for at least 3 months and plans to continue the same dose for the duration of the study

You may not qualify if…

• Contraindication to MRI (i.e. metallic implants, severe claustrophobia, weight above 320lb)
• Contraindication to phlebotomy (i.e. no accessible veins, hemoglobin <10 mg/dL)
• History of pancreatic disease other than diabetes
• Regular use of more than 2 alcoholic drinks per day
• Pregnancy
• Non-English speaking

Where it is running

• University of Texas Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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