Effect Of Obesity On Ozone-Induced Airway Inflammation

Completed · Not applicable

Conditions studied: Obesity

In brief

The purpose of this study is to compare the effect of ozone exposure on airway reactivity and inflammation in obese vs. non-obese adults.

Key facts

Study ID

NCT00839943

Run by

University of North Carolina, Chapel Hill

People needed

40

Starts

2006-05-01

Expected to finish

2012-02-01

Last updated by the study team

2012-08-27

Who can join

Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Twenty (20) non-obese, non-overweight (body mass index, 18 kg/m2 > BMI < 25 kg/m2, waist circumference < 35 inches) subjects and 20 obese (30 kg/m2 > BMI < 38 kg/m2, waist circumference >= 35 inches) volunteer females between 18-35 yrs of age

You may not qualify if…

• Are female and pregnant or have any reason to believe you might be pregnant.
• Are not between 18 and 35 years old.
• Have a history of asthma or have current hay fever.
• Have ever smoked more than 10 cigarettes (one half pack) a month or smoked during the past 30 days.
• Have a history of acute or chronic cardiovascular disease, chronic respiratory disease, and acute respiratory illness within 4 weeks.
• Have contraindications for performing sustained light exercise.
• You've been in a recent or recurring exposure to a dusty environment at work
• If you are unwilling to refrain from strenuous physical activity for 24 hours before and after each exposure.

Where it is running

• US EPA Human Studies Facility-UNC -CH campus — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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