Peripheral Immunologic Response of Solid Organ Transplant Recipients to Depletion Versus Non-depletion Protocols

Completed

Conditions studied: Liver Disease, Liver Transplantation

In brief

Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune response in solid organ transplant recipients. Direct measurement of the number and functions of the immune cells themselves using multi-parameter flow cytometry may enable individualized immunosuppression management for organ transplant recipients. Multi-parameter flow cytometry will be used to compare levels and functional capabilities of multiple lymphocyte subsets between cohorts of patients receiving depletion induction and those receiving a non-depletion regimen. The activation state, cytotoxic potential and the functional capabilities of these cells will be examined within patients over the first six months post transplant.

Key facts

Study ID

NCT00839709

Run by

University of Washington

People needed

30

Starts

2009-03-01

Expected to finish

2011-02-01

Last updated by the study team

2011-03-03

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• liver transplant recipient

You may not qualify if…

• none

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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