Airway Secretion Clearance in Cystic Fibrosis
Stopped early · Not applicable
Conditions studied: Cystic Fibrosis
In brief
The purpose of this study is to compare the effect of three airway secretion clearance techniques (chest physical therapy, flutter device and high frequency chest wall oscillation) on decline in pulmonary function over a three year period in patients with cystic fibrosis.
Key facts
- Study ID
- NCT00839644
- Run by
- University of Colorado, Denver
- People needed
- 166
- Starts
- 1999-12-01
- Expected to finish
- 2003-06-01
- Last updated by the study team
- 2012-10-02
Who can join
Age: 7 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A proven diagnosis of CF as evidenced by a positive sweat test (as documented by a sweat chloride >60 mEq/L by quantitative pilocarpine iontophoresis), or by the presence of two known CF mutations.
- Aged 7 or older.
- FEV1 >45% (Knudson).
- Able to perform reproducible maneuvers for spirometry at screening as defined by the American Thoracic Society (ATS) and European Respiratory Society (ERS) guidelines.
- Willing to participate in and comply with the study procedures, and willingness of a parent or legally authorized representative to provide written informed consent.
You may not qualify if…
- Hospitalization for complications of CF, or a respiratory exacerbation resulting in - treatment with IV antibiotics within 60 days prior to screening.
- Use of any investigational drug or device within 60 days prior to screening.
- An episode of gross hemoptysis (>249 ml) within 60 days prior to screening, or during the course of the study.
- A pneumothorax in the six months preceding the study or during the course of the study.
- Patients who are pregnant or become pregnant.
- Patients colonized with Burkholderia cepacia.
Where it is running
- University of Colorado Denver and The Children's Hospital — Denver, Colorado, United States
Full record on ClinicalTrials.gov
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