Evaluation of Pascal Laser Trabeculoplaty

Completed · Not applicable

Conditions studied: Open Angle Glaucoma, Ocular Hypertension

In brief

Laser Trabeculoplasty has been shown to be effective in lowering intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG). Although initially demonstrated with the Argon laser (ALT), several other laser systems have also been employed with comparable efficacy. Recently, Selective Laser Trabeculoplasty (SLT) has been shown to lower intraocular pressure comparable to ALT. The advantage of SLT is that the target eye structure, the trabecular meshwork, remains intact with minimal damage at the cellular level. In contrast, ALT lowers IOP at the expense of scarring of the trabecular meshwork. The purpose of this study is to evaluate the efficacy of lowering IOP with Pascal Laser Trabeculoplasty (PLT) employing reduced energy levels compared to ALT and a computer guided pattern of laser treatment applications.

Key facts

Study ID: NCT00838721
Run by: Santa Clara Valley Health & Hospital System
People needed: 50
Starts: 2008-03-01
Expected to finish: 2010-03-01
Last updated by the study team: 2016-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Otherwise healthy males and females, older than 18 years of age with two (2) sighted eyes
Have OAG, PXG, or combined mechanism glaucoma - as long as their angles are open
Have uncontrolled IOP (>24mmHg); or controlled with Medicine(s)
If on medical treatment, have undergone a washout period of at least one month prior to Pascal treatment
Able and willing to comply with the treatment/follow-up schedule and requirements;
Able to provide written informed consent

You may not qualify if…

Pregnant, intending to become pregnant during course of study, less than 3 months postpartum or less than 6 weeks after completion of breastfeeding
Have an advanced visual field defect within 10° of fixation
Have had previous glaucoma surgery, except for peripheral iridotomy
Have corneal disease obviating the use of corneal applanation for a reliable IOP measurement, or would cause difficulty in viewing the TM by means of gonioscopic lens
Using systemic steroids
Participation in a study of another device or drug within 3 month prior to study enrollment or during this study, and as per the Investigator's careful discretion, as long as not contradictory to any of the above criteria
Any condition which, in the Investigator's opinion, would make it unsafe (for the subject or for the study personnel) to treat the subject as part of this research study
No concomitant use of IOP lowering medicine (Group 1)
No co-existing ocular pathology with the exception of Cataract.

Where it is running

Santa Clara Valley Medical Center — San Jose, California, United States

Full record on ClinicalTrials.gov

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