Variability in Adrenergic Response

Completed · Not applicable

Conditions studied: Vascular Reaction to Medications

In brief

The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.

Key facts

Study ID

NCT00838695

Run by

Vanderbilt University

People needed

106

Starts

2009-01-01

Expected to finish

2011-12-01

Last updated by the study team

2018-10-26

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 and 40 years, inclusive.
• Subject must be willing to give written informed consent and be able to adhere to diet and study schedules.
• Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with the study evaluations.
• Subjects must have a normal or clinically acceptable physical examination and ECG.
• Clinical laboratory tests (CBC, blood chemistries, and urinalysis) must be within normal limits or clinically acceptable to the investigator.

You may not qualify if…

• Any subject who has taken any prescription or over-the-counter drugs, other than oral contraception if female, within two weeks prior to study drug administration.
• Subjects who are presently, or were formerly, narcotic addicts or alcoholics.
• Subjects who have a clinically significant allergy/intolerance to phenylephrine.
• Females with a positive serum/urine pregnancy test at screening.
• Females who are nursing.
• Subject using sildenafil or other phosphodiesterase inhibitors.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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