Effects of Antipsychotic Medications on Energy Intake and Expenditure

Completed

Conditions studied: Schizophrenia, Schizoaffective Disorder, Weight Gain

In brief

Aim 1: To evaluate the effect of antipsychotic treatment group on Activity Energy Expenditure. The project hypothesizes that subjects treated with olanzapine will demonstrate a greater decrease in AEE over time than subjects treated with ziprasidone, due at least in part to sedating effects of olanzapine. Aim 2: To evaluate the effect of antipsychotic treatment group on Energy Intake. The project hypothesizes that subjects treated with olanzapine will demonstrate a greater increase in EI over time than subjects treated with ziprasidone, based on higher histamine type 1 (H1) receptor affinity of olanzapine and the relationship between H1 affinity and hunger and/or satiety.

Key facts

Study ID

NCT00836251

Run by

Washington University School of Medicine

People needed

15

Starts

2006-04-01

Expected to finish

2008-06-01

Last updated by the study team

2014-03-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• non-diabetic
• schizophrenic or schizoaffective
• currently prescribed olanzapine or ziprasidone
• 18-80 y.o.

You may not qualify if…

• <18 or >80 years of age
• diabetic
• not schizophrenic or schizoaffective
• not currently prescribed olanzapine or ziprasidone

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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