Axitinib (AG-013736) With Or Without Dose Titration (Increase) In Patients With Kidney Cancer

Completed · Phase 2 · Has a placebo group

Conditions studied: Carcinoma, Renal Cell

In brief

Axitinib dose titration (giving a higher dose of the drug above its standard starting dose) among certain patients may improve the response to treatment.

Key facts

Study ID

NCT00835978

Run by

Pfizer

People needed

213

Starts

2009-08-01

Expected to finish

2016-02-01

Last updated by the study team

2017-05-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• metastatic renal cell carcinoma (kidney cancer) with clear cell component
• no prior systemic therapy (including no prior adjuvant or neoadjuvant)
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1
• Blood Pressure < or = 140/90mmHg

You may not qualify if…

• brain/CNS metastasis
• using more than 2 blood pressure medications

Where it is running

• Comprehensive Blood and Cancer Center — Bakersfield, California, United States
• Bay Area Cancer Research Group, LLC — Pleasant Hill, California, United States
• Diablo Valley Oncology and Hematology Medical Group Inc — Pleasant Hill, California, United States
• East Bay Medical Oncology/Hematology Medical Associates Inc — Pleasant Hill, California, United States
• East Bay Medical Oncology/Hematology Medical Associates Inc — San Leandro, California, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• Investigational Drug Services, IUHSCC — Indianapolis, Indiana, United States
• IU Health University Hospital — Indianapolis, Indiana, United States
• University of Maryland Greenebaum Cancer Center — Baltimore, Maryland, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Cancer and Hematology Centers of Western Michigan — Grand Rapids, Michigan, United States
• Barnes-Jewish Hospital — St Louis, Missouri, United States
• Washington University — St Louis, Missouri, United States
• Nebraska Methodist Hospital — Omaha, Nebraska, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• Nevada Cancer Institute — Las Vegas, Nevada, United States
• The University Hospital — Cincinnati, Ohio, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• The Ohio State University, James Cancer Hospital — Columbus, Ohio, United States
• East Bay Medical Oncology/Hematology Medical Associates Inc. — Antioch, California, United States

Full record on ClinicalTrials.gov

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