Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Nausea, Vomiting

In brief

The combination of aprepitant and lower dose dexamethasone is superior to aprepitant alone with respect to the proportion of patients with a complete response (no vomiting and no use of rescue therapy) during 24 hours after the placement of last suture/staple.

Key facts

Study ID

NCT00835965

Run by

Main Line Health

People needed

50

Starts

2009-02-01

Last updated by the study team

2009-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• at least 18 years old
• ASA physical status I-III
• must have at least 2 risk factors for PONV

You may not qualify if…

• pregnant or breast feeding patients
• antiemetic medication in previous 24 hours
• allergy or other contraindication to study medications

Where it is running

• Lankenau Hospital — Wynnewood, Pennsylvania, United States

Full record on ClinicalTrials.gov

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