Treatment Trial for Psychogenic Nonepileptic Seizures

Completed · Phase 4

Conditions studied: Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic, Dissociative Disorders

In brief

The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline) will report fewer nonepileptic seizures (NES) compared to patients who receive community care / treatment as usual (TAU). The purpose of this study is to provide pilot testing and data to inform the future multicenter randomized controlled trial based on the hypothesis.

Key facts

Study ID

NCT00835627

Run by

Rhode Island Hospital

People needed

38

Starts

2008-09-01

Expected to finish

2013-06-01

Last updated by the study team

2014-11-10

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Video electroencephalogram (EEG) confirmed diagnosis of NES
• Have at least one nonepileptic seizure per month
• Able to complete self report symptom scales
• Not receiving optimized sertraline

You may not qualify if…

• Equivocal EEG findings
• using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan
• allergy/sensitivity to sertraline
• current alcohol/drug dependence
• serious medical illness requiring current hospitalization

Where it is running

• Stanford University — Stanford, California, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Rhode Island Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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