Safety and Efficacy of L-NAME and Midodrine to Increase MAP
Completed · Phase 2 · Has a placebo group
Conditions studied: Orthostatic Hypotension, Spinal Cord Injury
In brief
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day in persons with spinal cord injury.
Key facts
- Study ID
- NCT00835224
- Run by
- US Department of Veterans Affairs
- People needed
- 34
- Starts
- 2010-05-01
- Expected to finish
- 2013-08-01
- Last updated by the study team
- 2014-04-23
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Spinal Cord Injured Subjects:
- chronic spinal cord injury (1 year post injury) with a seated MAP of 65mmHg (almost all individuals with tetraplegia demonstrate this)
- Male or female with an age of 18 - 65 years
- Control Subjects:
- Male or female with an age of 18 - 65 years
You may not qualify if…
- Spinal Cord Injured Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
- Control Subjects:
- acute illness
- cardiovascular disease
- renal disease
- medications that affect the cardiovascular system
Where it is running
- VA Medical Center, Bronx — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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