Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight

Completed · Phase 4

Conditions studied: Depression

In brief

This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.

Key facts

Study ID

NCT00834652

Run by

Washington University School of Medicine

People needed

206

Starts

2007-09-01

Expected to finish

2013-05-01

Last updated by the study team

2018-09-10

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body mass index (BMI) greater than 28.7
• Positive screening for depression
• Must live within 100 miles of the St. Louis metropolitan area

You may not qualify if…

• Pregnant or breastfeeding
• Known hypersensitivity to sertraline or metformin
• Recent history of heart attack or unstable heart disease
• Severe liver disease or kidney impairment, defined by a serum creatine level above 3 mg/dL
• Psychiatric disorder thought to affect management, such as schizophrenia, or alcohol or drug dependence

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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