Renin Profiling in Selection of Initial Antihypertensive Drug

Completed · Not applicable

Conditions studied: Hypertension

In brief

The purpose of this research study is to determine whether a simple blood test measuring a hormone called renin can better determine which first drug would be most effective in controlling blood pressure, in comparison with the more traditional approach recommended by JNC7 (Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure).

Key facts

Study ID

NCT00834600

Run by

The Louis & Rachel Rudin Foundation

People needed

185

Starts

2005-12-01

Expected to finish

2011-10-01

Last updated by the study team

2012-04-19

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females, 40 to 85 years of age
• Sustained systolic blood pressure between 140-180 mm Hg
• Free of antihypertensive therapy at randomization for at least 4 weeks

You may not qualify if…

• Ages <40, or >85 years
• Systolic blood pressure >180 mm Hg
• Blood pressure >180/105 mm Hg during the washout period
• Require antihypertensive agents for non-blood pressure indications
• Taking clonidine
• On a beta-blocker drug and have known or suspected coronary artery disease
• Documented history of a heart attack, new onset of chest pain, or a coronary revascularization procedure within the past year, congestive heart failure
• Serious intercurrent illness
• An active ulcer
• Have certain abnormal laboratory tests (elevated serum creatinine >1.5 mg/dl, transaminase > 2 times upper limit of normal or active liver disease),
• Hypersensitivity, allergy or have an intolerance to angiotensin II receptor blockers (olmesartan), hydrochlorothiazide or amlodipine
• Mentally or legally unable to participate
• Have or are currently abusing alcohol, have abused drugs within the past 2 years
• Have been in another drug study in the past month.

Where it is running

• Lincoln Medical and Mental Health Center — The Bronx, New York, United States
• Albert Einstein College of Medicine - GCRC — The Bronx, New York, United States
• Jacobi Medical Center — The Bronx, New York, United States
• Bronx Nephrology Hypertension, PC — The Bronx, New York, United States
• Ralph Yung, MD — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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