Escitalopram (Lexapro) for the Treatment of Postpartum Depression

Completed · Phase 4

Conditions studied: Postpartum Depression

In brief

The purpose of this study is to determine whether women with postpartum major depressive disorder (MDD) will experience a significant decrease in depressive symptoms from baseline over an eight-week treatment intervention with escitalopram (Lexapro). Also, to determine whether women with postpartum MDD will experience a significant decrease in anxiety symptoms.

Key facts

Study ID

NCT00833469

Run by

Massachusetts General Hospital

People needed

7

Starts

2009-01-01

Expected to finish

2011-04-01

Last updated by the study team

2014-08-06

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women ages 18 to 45 years old
• Subjects must meet criteria for a major depressive episode with symptoms developing within three month of live childbirth
• Subjects must present within six months of childbirth
• MADRS score >15
• BAI score >10
• Subjects will be able to be treated on an outpatient basis
• Subjects will be able to provide written informed consent

You may not qualify if…

• Subjects who have taken any psychotropic medication, including antidepressants and anti-anxiety medication, within the past two weeks (with the exception of non-benzodiazepine medications used for sleep, including trazodone, zolpidem, eszopiclone, etc)
• Suicidal ideation with active plan or intent, as determined by the investigator
• Presence of psychotic symptoms or homicidal ideation
• History of mania or hypomania
• Pregnant or breastfeeding
• Presence of chronic depression or dysthymia, or chronic or treatment resistant anxiety disorders, as determined by investigator
• Active alcohol/substance abuse currently or within the past year
• Abnormal TSH, severe anemia, or uncontrolled hypertension

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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