A Phase 1 Study of IXAZOMIB in Adult Patients With Advanced Nonhematologic Malignancies

Completed · Phase 1

Conditions studied: Advanced Non-hematologic Malignancies

In brief

This is an open-label, multicenter, phase 1, dose escalation study of IXAZOMIB. The primary purpose of this study is to determine the safety profile, establish the maximum tolerated dose, and inform the phase 2 dose of IXAZOMIB administered intravenously in participants with nonhematologic malignancies.

Key facts

Study ID: NCT00830869
Run by: Millennium Pharmaceuticals, Inc.
People needed: 116
Starts: 2009-03-02
Expected to finish: 2012-04-20
Last updated by the study team: 2019-09-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Each participant must meet all of the following inclusion criteria to be enrolled in the study:
Male or female participants 18 years or older.
Eastern Cooperative Oncology Group performance status 0-2.
A diagnosis of a nonhematologic malignancy for which standard treatment is no longer effective. In the expanded cohort, enrollment will be limited to participants with a diagnosis of NSCLC, H\&N cancer (squamous cell cancer), STS, or PC.
Suitable venous access for pharmacokinetic (PK) and pharmacodynamic evaluations.
Female participants who are post menopausal, surgically sterile, or agree to practice 2 effective methods of contraception or abstain from heterosexual intercourse.
Male participants who agree to practice 2 effective methods of contraception or abstain from heterosexual intercourse.
Voluntary written consent must be obtained.
Adequate clinical laboratory values during the screening period.
In the escalation portion of the study, radiographically or clinically evaluable tumor was required, but measurable disease as defined by response evaluation criteria in solid tumors (RECIST) criteria was not required. In the MTD disease expansion cohorts and the TPEC, clinically measurable disease as defined by RECIST criteria was required for evaluation of NSCLC, H\&N cancer, and STS. Prostate specific antigen (PSA) alone was acceptable for evaluation of PC.
For participants in the TPEC, tumor tissue that, in the opinion of the investigator, could have been safely biopsied using a core needle.

You may not qualify if…

Participants meeting any of the following exclusion criteria are not to be enrolled in the study:
Peripheral neuropathy greater than or equal to (>=) Grade 2.
Female participants who are lactating or have a positive serum pregnancy test during the screening period.
Major surgery within 14 days before the first dose of treatment.
Infection requiring systemic antibiotic therapy or other serious infection within 14 days before the first dose of study treatment.
Life-threatening illness unrelated to cancer.
Diarrhea greater than (>) Grade 1 based on the National Cancer Institute Common Terminology .Criteria for Adverse Events (NCI CTCAE) categorization.
Systemic antineoplastic therapy / or radiotherapy within 21 days before the first dose of study treatment.
Systemic treatment with prohibited medications.
Participant has symptomatic brain metastasis.
Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure (CHF), angina, or myocardial infarction within the past 6 months.
QTc >470 milliseconds (msec) on a 12-lead electrocardiogram (ECG) obtained during the screening period.
Known human immunodeficiency virus (HIV), hepatitis B or hepatitis C positive.
Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol.
Treatment with any investigational products within 28 days before the first dose of study treatment.
For participants in the TPEC and participants in the MTD disease expansion cohorts who gave informed consent to undergo tumor biopsy, ongoing anticoagulant therapy (example, aspirin, clopidogrel [Plavix ®], warfarin, or heparin) that cannot be held to permit tumor biopsy .
Known allergy to boron or excipients.

Where it is running

H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
Emory University — Atlanta, Georgia, United States
University of Michigan — Ann Arbor, Michigan, United States
Duke University — Durham, North Carolina, United States
Sarah Cannon Research Institute — Nashville, Tennessee, United States
University of Washington- Seattle Cancer Care — Seattle, Washington, United States
Princess Margaret Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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