Beta-blockade Effects on Memory for Cocaine Craving

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine Dependence

In brief

The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.

Key facts

Study ID

NCT00830362

Run by

Medical University of South Carolina

People needed

50

Starts

2009-02-01

Expected to finish

2011-07-01

Last updated by the study team

2012-11-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current cocaine dependence (within past month)
• Able to provide informed consent
• Use of birth control by female participants (barrier methods, surgical sterilization, IUD, or abstinence)
• Live within 50-mile radius of research site
• Consent to remain abstinent from all drugs of abuse (except nicotine) for 24 hours prior to inpatient admission and follow-up assessment
• Consent to random assignment to propranolol or placebo

You may not qualify if…

• Women who are pregnant, nursing or are of childbearing potential and not practicing/using birth control
• Evidence or history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal or neurological disease
• Significant liver impairment
• History of or current psychotic disorder, current severe major depressive disorder, bipolar affective disorder or a severe anxiety disorder
• Currently taking anti-arrhythmic agents, psychostimulants or other agents known to interfere with heart rate and skin conductance monitoring
• Known or suspected hypersensitivity to propranolol
• Individuals taking medications that could adversely interact with the study medication, including, but not limited to albuterol, insulin, or significant inhibitors of CYP2D6
• Individuals with bronchial asthma or chronic obstructive pulmonary disease

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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