The Effect of Treatment on Circulating Tumor Cells in Bladder Cancer Patients With Muscle-invasive or Advanced Disease

Completed

Conditions studied: Bladder Cancer

In brief

The investigators hypothesize that circulating tumor cells (CTC) will be observed in patients with muscle-invasive or metastatic bladder cancer and that CTC will become undetectable, at least transiently, in a fraction of patients after treatment. To investigate this hypothesis, investigators will assess the levels of CTCs both before and after treatment. The feasibility and potential value of fluorescent in situ hybridization (FISH) in the CTCs will be assessed.

Key facts

Study ID

NCT00829920

Run by

University of Colorado, Denver

People needed

44

Starts

2008-11-01

Expected to finish

2013-02-01

Last updated by the study team

2013-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pathological diagnosis of transitional cell carcinoma of the urothelium of at least T2-4, Nx, Mx stage. Mixed histologies will be allowed (e.g. squamous differentiation) as long as a transitional cell component is present.
• Clinical plans for surgery (with or without chemotherapy), radiation therapy, or chemotherapy.
• Participants must not have any condition which in the investigator's opinion may compromise the feasibility of completing the study.
• Subject must be 18 years of age or older
• Subject must be willing to have up to 4 peripheral blood samples obtained over a 6 month period of study.
• Prior therapies for bladder cancer will be allowed if patient currently has muscle-invasive or metastatic bladder cancer despite the previous treatments.
• Predicted life expectancy of > 12 weeks.

You may not qualify if…

• Subjects who are unwilling or unable to comply with the study guidelines as determined by the principal investigator.

Where it is running

• University of Colorado Hospital — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.