Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis
Withdrawn before enrolling · Early Phase 1
Conditions studied: Recurrent Respiratory Papillomatosis
In brief
The purpose of this study is to determine if administration of the HPV quadrivalent vaccine in patients diagnosed with RRP has a therapeutic effect on their clinical course. More specifically, does administration of the vaccine decrease the size and number of papillomas, severity of disease (i.e. hoarseness, inspiratory vs. biphasic stridor, airway obstruction) using the LCAS and time interval between required surgical debulking will be analyzed.
Key facts
- Study ID
- NCT00829608
- Run by
- University of Missouri-Columbia
- People needed
- 0
- Starts
- 2009-01-01
- Expected to finish
- 2010-06-01
- Last updated by the study team
- 2016-10-05
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- There are 9 participants currently being followed in the faculty sponsor's clinic that carry the clinical and histologic diagnosis of RRP. The 9 participants meet one or more of the following criteria: Surgery requirement of more than 4 procedures per year, distal multisite spread of disease, and rapid regrowth of papilloma disease with airway compromise.
You may not qualify if…
- If any of the 9 patients meet the following criteria they will be excluded from the study:
- Pregnancy
- Hypersensitivity or allergy to vaccine components (i.e. Saccharomyces cerevisiae yeast)
- Immunocompromised patients (i.e. patients with HIV, cancer, or who take immunosuppressant medications including all forms of steroids)
- Have a fever over 100°F (37.8°C)
- Moderate or severe acute illness (with or without fever)
- Coagulopathies
- Platelet counts of less than 100,000
- Any history of recent treatment(within 3 months) with any investigational drug or other adjuvant RRP therapy (including interferon-gamma, ribavirin, acyclovir, cidofovir and photodynamic therapy, indole-3-carbinol)
Where it is running
- University of Missouri — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.