Pharmacokinetic Properties of Lorcaserin in Obese or Overweight Elderly Subjects

Completed · Phase 1

Conditions studied: Obesity

In brief

The purpose of this study is to evaluate the PK properties of lorcaserin in obese or overweight elderly subjects.

Key facts

Study ID

NCT00828581

Run by

Eisai Inc.

People needed

24

Starts

2008-10-01

Expected to finish

2008-12-01

Last updated by the study team

2023-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females
• Control (Adult) group: aged between 18 and 65 years (inclusive)
• Elderly group: aged > 65 years (includes subjects 1 day or more beyond the 65th birthday)
• Able to give signed informed consent
• BMI 27-45 kg/m2, inclusive 6. Eligible male and female subjects must agree not to participate in a conception process (i.e. active attempt to become pregnant or to impregnate, egg or sperm donation, in vitro fertilization).
• Considered to be in stable health in the opinion of the Investigator

You may not qualify if…

• Prior participation in any study of lorcaserin.
• Clinically significant new illness in the 1 month before screening
• Not suitable to participate in the study in the opinion of the Investigator including an existing physical or mental condition that prevents compliance with the protocol
• History of any of the following cardiovascular conditions:
• Myocardial infarction (diagnosed by cardiac enzyme[s] and/or diagnostic ECG), cerebral vascular accident (CVA), transient ischemic attack (TIA) or reversible ischemic neurologic deficit (RIND) within 6 months of screening
• Cardiac arrhythmia requiring initiation of new medical or surgical treatment within 6 months of screening (stable medical therapy for > 6 months, pacemakers and/or defibrillators implanted > 6 months prior to screening are acceptable)
• Unstable angina
• History of pulmonary artery hypertension
• Positive result of HIV, hepatitis B or hepatitis C screens
• Initiation of a new prescription medication within 1 month prior to screening with the following exceptions:
• Use of SSRIs, SNRIs, and other medications must meet washout period.
• Participated in any clinical study with an investigational drug, biologic, or device within 1 month prior to screening

Where it is running

• CRI Worldwide - Lourdes Hospital — Willingboro, New Jersey, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.