Genetic Regulation of Surfactant Deficiency

Completed

Conditions studied: Respiratory Distress Syndrome, Newborn

In brief

Inherited deficiencies in any one of 3 genes (surfactant protein B, surfactant protein C, and ATP-binding cassette transporter A3) can cause neonatal respiratory distress syndrome by disrupting metabolism of the pulmonary surfactant. The investigators will use state of the art methods to link specific changes in the genetic code of each of these genes with disruption of discrete steps in the metabolism of the pulmonary surfactant in human newborn infants. These studies will lead to improved diagnostic capabilities and suggest novel strategies to correct surfactant deficiency in newborn infants.

Key facts

Study ID

NCT00828243

Run by

Washington University School of Medicine

People needed

525

Starts

2007-11-01

Expected to finish

2013-03-01

Last updated by the study team

2021-06-07

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newborn infants with respiratory distress syndrome who require mechanical ventilation via endotracheal tube or tracheostomy in the first 6 months of life

You may not qualify if…

• Infants with conditions likely to cause imminent death

Where it is running

• St. Louis Children's Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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