BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Completed · Phase 2
Conditions studied: Lung Cancer
In brief
RATIONALE: Vaccines may help the body build an effective immune response to kill tumor cells. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving vaccine therapy together with bevacizumab after chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving BLP25 liposome vaccine together with bevacizumab after chemotherapy and radiation therapy in treating patients with newly diagnosed stage IIIA or stage IIIB non-small cell lung cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00828009
- Run by
- ECOG-ACRIN Cancer Research Group
- People needed
- 70
- Starts
- 2011-01-17
- Expected to finish
- 2019-05-22
- Last updated by the study team
- 2023-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Stanford Cancer Center — Stanford, California, United States
- Medical Center of Central Georgia — Macon, Georgia, United States
- St. Joseph Medical Center — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Memorial Hospital — Carthage, Illinois, United States
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
- Hematology and Oncology Associates — Chicago, Illinois, United States
- Saint Joseph Hospital — Chicago, Illinois, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- Eureka Community Hospital — Eureka, Illinois, United States
- Galesburg Clinic, PC — Galesburg, Illinois, United States
- Ingalls Cancer Care Center at Ingalls Memorial Hospital — Harvey, Illinois, United States
- Mason District Hospital — Havana, Illinois, United States
- Kellogg Cancer Care Center — Highland Park, Illinois, United States
- Hinsdale Hematology Oncology Associates — Hinsdale, Illinois, United States
- Provena St. Mary's Regional Cancer Center - Kankakee — Kankakee, Illinois, United States
- North Shore Oncology and Hematology Associates, Limited - Libertyville — Libertyville, Illinois, United States
- McDonough District Hospital — Macomb, Illinois, United States
- Trinity Cancer Center at Trinity Medical Center - 7th Street Campus — Moline, Illinois, United States
- Cancer Care and Hematology Specialists of Chicagoland - Niles — Niles, Illinois, United States
- BroMenn Regional Medical Center — Normal, Illinois, United States
- Community Cancer Center — Normal, Illinois, United States
- Community Hospital of Ottawa — Ottawa, Illinois, United States
- Cancer Treatment Center at Pekin Hospital — Pekin, Illinois, United States
- Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
Full record on ClinicalTrials.gov
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