Strength Training for Skeletal Muscle Adaptation After Stroke

Completed · Not applicable

Conditions studied: Stroke

In brief

Chronically disabled stroke survivors experience accelerated skeletal muscle atrophy and other detrimental changes to muscle and surrounding tissues on the paretic side. This unilateral tissue-level damage contributes to worsening disability and insulin resistance. This VA Merit Award will advance the investigators' understanding of the potential for strength training (ST) to reverse stroke-related muscle abnormalities to improve metabolic health, strength, and function. It will be the first study to thoroughly investigate the effects of ST on muscle atrophy, intramuscular fat, muscle fiber characteristics, capillary density and insulin sensitivity after stroke.

Key facts

Study ID

NCT00827827

Run by

VA Office of Research and Development

People needed

38

Starts

2009-04-01

Expected to finish

2018-06-06

Last updated by the study team

2018-07-09

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stroke greater than 6 months prior with residual hemiparetic gait in women or men aged 40-85 years
• Completion of all regular post-stroke physical therapy
• Adequate language and neurocognitive function to participate in testing and training and to give adequate informed consent

You may not qualify if…

• Alcohol consumption greater than 3 oz. liquor, or 3 x 4 oz glasses of wine, or 3 x 12 oz. beers per day, by self-report
• clinical history of:
• unstable angina
• recent (less than 3 months) myocardial infarction or congestive heart failure (NYHA category II)
• hemodynamically significant valvular dysfunction
• peripheral arterial occlusive disease (PAOD) with claudication
• major orthopedic, chronic pain, or non-stroke neuromuscular disorders restricting exercise
• pulmonary or renal failure
• poorly controlled hypertension (greater than 190/110)
• recent hospitalization for severe disease or surgery
• severe or global receptive aphasia which confounds reliable testing and training
• Allergy to lidocaine
• Known muscle disorder
• Taking Coumadin or Lovenox (contraindication for muscle biopsies)
• Dementia
• Untreated major depression

Where it is running

• Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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