Effect of Inhaled Steroids on Gene Expression in the Lungs - 2
Stopped early · Phase 4
Conditions studied: Chronic Obstructive Pulmonary Disease (COPD)
In brief
The purpose of this study is to assess the effect of inhaled beclomethasone (an inhaled corticosteroid) on the pattern of the lung airway epithelium and alveolar macrophages gene expression of healthy smokers. We hypothesize that the administration of beclomethasone will result in reversibility of some of the airway epithelium and alveolar macrophage gene expression changes induced by cigarette smoking.
Key facts
- Study ID
- NCT00826748
- Run by
- Weill Medical College of Cornell University
- People needed
- 24
- Starts
- 2010-11-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2018-01-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All Smokers (Treated and Non-Treated)
- All study individual should be enrolled in Weill-IRB protocol #0005004439 entitled "Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"
- All study subjects should be able to provide informed consent
- Current smokers with 15-to 40 pack-year history
- All study individuals should be healthy as per protocol #0005004439 entitled "Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"
- Non-Smokers
- All study individual should be enrolled in Weill-IRB protocol #0005004439 entitled "Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"
- All study subjects should be able to provide informed consent
- All study individual should be healthy as per protocol #0005004439 entitled "Evaluation of the Lungs of Normal (Smokers, Ex-smokers, Non-Smokers) Individuals with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy"
You may not qualify if…
- All Smokers
- Smokers intending to quit smoking in the next 14 days.
- Individuals already receiving any lung related inhalers
- Females who are pregnant or nursing
- Non-Smokers
- Exclusion Criteria:
- Non-smokers who intend to start smoking in the next 14 days
- Individuals already receiving any lung related inhalers
- Females who are pregnant or nursing
Where it is running
- Weill Cornell Medical College — New York, New York, United States
Full record on ClinicalTrials.gov
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